The present study sought to examine the effects of minocycline (MH), its nanoparticles (MH NP) and ligand coated nanoparticles (coated MH NP) on anxiety in mice. The treatment protocol included injections of MH (100 mg/kg, i.p.), MH NP (equivalent to 100 mg/kg MH, i.p.) and coated MH NP (equivalent to 100 mg/kg MH, i.p.) at two different time intervals. The novel Elevated Plus Maze (EPM) test and Light/dark test were employed to assess anti-anxiety properties of the MH, MH NP and coated MH NP. The experimental outcome revealed that neither EPM nor Light/dark test exhibited any alteration in anxiety levels, although MH has been reported to exhibit significant antidepressant activity, comparable to that of amitriptyline. It may be concluded that although nanoparticles improved brain uptake of MH, but still they may not be a suitable candidate for therapeutic management of anxiety.
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